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What We Offer

Five Ways We Accelerate
Your Drug Development Pipeline.

From single compound screening to full ex vivo clinical trial support — every engagement is built around your scientific question, not a catalogue package.

Jump to Services ↓Request a Quote →(Get an instant service proposal)
Our Approach

We Don't Just Sell Packages. We Design Experiments.

Every project at 3DxCell begins with a scientific discussion. We consider your compound, target, timeline, and constraints — then design an organoid-based study tailored to your specific question.

Our service areas provide structured starting points, but each project is customized to fit your scientific and strategic needs.

Projects are scoped individually, and pricing reflects the specific study design, complexity, and objectives.

Science-first scoping

Your question drives the design — not a menu

Formal proposal process

You receive a documented scientific proposal before any work begins

Confidential by default

All project data is treated as confidential; NDAs signed before data sharing

Core Services

Five Service Areas. One Integrated Platform.

Integrated organoid solutions across drug development and clinical strategy.

We apply your compound(s) — or a panel of candidates — to validated patient-derived organoid models representing your tumor type of interest. Drug response is quantified using dose-response assays, viability readouts, and IC50 determination.

DeliverableDetail
Dose-response curvesIC50 per compound per organoid model
Viability heatmap% cell viability across compound panel
Compound ranking reportRanked by efficacy signal in PDO models
Methodology appendixFull protocol documentation for regulatory use
Raw data filesExport-ready for your internal analysis

Typical scope: 1–5 PDO models, 1–50+ compounds. ~3–4 weeks from tissue intake.

Start a Screening Project →

We test rational drug combinations — typically 2 agents — on patient-derived organoids to generate a combination response matrix. Using established synergy models (Loewe Additivity, Bliss Independence, HSA), we classify each pairing.

DeliverableDetail
Combination matrix heatmapSynergy scores across dose combinations
Synergy classificationLoewe / Bliss / HSA model outputs
Decision reportPrioritised recommendations with scientific rationale

Typical scope: 2–6 compounds in matrix, 2–5 PDO models. ~4 weeks.

Design a Combination Study →

We use patient-derived organoids to generate ex vivo response data that supports clinical trial design, patient stratification, and cohort selection. This approach helps identify responsive subgroups, explore biomarker-driven stratification strategies, and better understand variability in treatment response.

DeliverableDetail
Cohort response landscapeResponse rates across PDO models representing target population
Stratification signal reportIdentification of candidate biomarkers or subgroups associated with response
Trial design recommendationEnrollment criteria informed by PDO data
Regulatory-ready documentationProtocol suitable for IND/CTA filing
Full data packageRaw + interpreted, audit-trail ready

Typical scope: 10–60 PDO models, 1–3 compounds. 6–12 weeks for full cohort.

Explore Trial Support Options →

We generate patient-derived organoids from individual tumor biopsies and evaluate drug response in a structured research workflow. From tissue processing to molecular characterisation and drug testing, this generates detailed patient-specific research data to support translational and academic studies. All results are intended for research purposes.

DeliverableDetail
Organoid drug-response data setQuantified response across tested compound panel
Compound activity rankingCompounds ordered by signal strength in PDO models
Biomarker correlation analysisGenomic markers associated with response
Research summary reportStructured for translational research review

Important Note: 3DxCell provides preclinical research services. Our solutions are not intended for clinical diagnostic use or to guide individual patient treatment decisions. All clinical decisions remain the responsibility of the treating physician. We are actively working toward IVDR certification.

Typical scope: 1 patient (clinical) or 5–50 patients (research). ~3–5 weeks per patient.

Discuss a Precision Medicine Project →

Not every project fits a standard service. If you have a specific scientific question, a unique compound class, an unusual tumor indication, or a complex multi-arm study — we scope a custom workflow from scratch. This includes model development, custom assay design, longitudinal studies, resistance modeling, TME co-culture, and biomarker validation.

Process: Initial scientific call (30–60 min, no obligation) → Feasibility assessment (5 business days) → Formal proposal → Kickoff on agreement.

All custom projects are delivered with the same rigour, data quality, and documentation standards as our standard services.

Describe Your Project →
Capabilities

Technical Capabilities Behind Our Organoid Platform

Technologies, assays, and quality systems that drive every study.

Organoid Generation

  • Tissue dissociation (enzymatic + mechanical)
  • 3D culture (BME/Matrigel)
  • Tumor-specific growth optimisation
  • Passage stability validation (up to p10+)
  • Cryopreservation and recovery

Quality Control & Characterisation

  • H&E histomorphology
  • Immunofluorescence (IF) panel staining
  • NGS — SNV, CNV, mutational profiling
  • STR fingerprinting for identity verification

Drug Assay Formats

  • CellTiter-Glo luminescent cell viability
  • Calcein-AM / PI live-dead imaging
  • High-content imaging (brightfield + fluorescence)
  • Dose-response (8–10 point curves)
  • Combination matrices (up to 6×6)

Data Analysis & Reporting

  • IC50 / AUC calculation
  • Synergy scoring: Loewe, Bliss, HSA, ZIP
  • Responder / non-responder classification
  • Biomarker correlation analysis
  • GLP-aligned documentation on request
Getting Started

From First Discussion to Actionable Data in Four Steps

A structured, transparent path from intake call to delivered report.

  1. ~30–60 min

    Scientific Consultation

    Tell us about your compound, indication, and objective. We assess feasibility and ask the right questions. This call is free, informal, and confidential.

  2. 3–5 days

    Project Proposal

    We deliver a written proposal: study design, organoid models, assay formats, deliverables, timeline, and cost. Typically within 5 business days.

  3. 1–2 weeks

    Kickoff & Tissue Logistics

    Agreement signed. Tissue collection protocol shared. Dedicated project lead assigned. We coordinate biopsy logistics, shipping conditions, and timeline.

  4. ~4–6 weeks total

    Report & Debrief

    Final report delivered. We walk through findings, answer questions, and discuss implications for your pipeline. Data in export-ready formats.

Ready?

Let's Design Your Experiment.

Tell us about your compound and we'll come back with a tailored proposal.

Book a Meeting →(Discuss your project)Request a Quote →(Get an instant service proposal)